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I didn’t realise it was used in laundry products. Emerging data suggests this one may be a dermal irritant, associated with eczema and a possible neurotoxin. Methylisothiazolinone / Methylchloroisothiazolinone (MI/MCI), in combination. Background . Methylchloroisothiazolinone and Methylisothiazolinone in high concentrations are known to irritate the skin, and in extreme cases even cause a chemical burn to the skin. Importance: Contact allergy to methylisothiazolinone (MI) or to the combined formulation of methylchloroisothiazolinone and MI (MCI-MI) has increased significantly, with a frequency of as much as 11.1% in patients with dermatitis; however, few cohort studies in the US population have been reported. The preservative can still be used in rinse-off products, to a maximum concentration of 0.0015% or 15 ppm. The preservative methylisothiazolinone (MI) is the American Contact Dermatitis Society Contact Allergen of the Year for 2013. MCI is often used in combination with methylisothiazolinone, a mixture known as Kathon. Because the use of MI in cosmetics and toiletries in the United States rises, MI exposure also rises. Methylchloroisothiazolinone, also referred to as MCI, is the organic compound with the formula S(C 2 HCl)C(O)N(CH 3). Methylisothiazolinone, along with other isothiazolinones, is a biocide widely used as a preservative in personal care products. Two more ingredients to keep an eye on. In particular, earlier this year, the combination of methylisothiazolinone and methylchloroisothiazolinone was restricted, and the use of methylisothiazolinone by itself is scheduled to be banned in 2017. Ingredients to avoid: Methylisothiazolinone and Methylchloroisothiazolinone. The compound is an isothiazolinone, a class of heterocycles used as biocides. Methylisothiazolinone and Methylchloroisothiazolinone: the story of a blacklisted chemical These preservatives, like many others, regularly draw the attention of the cosmetics media. It should be listed as Methylchloroisothiazolinone (and) methylisothiazolinone on ingredient lists, so it isn’t too difficult to work out what to avoid in cosmetic products. Methylisothiazolinone and Methylchloroisothiazolinone Dr. Bergfeld opened the discussion by noting that this was the second time the Panel had reviewed this report and read the proposed conclusion for Methylisothiazolinone and Methylchloroisothiazolinone of safe as cosmetic Due to allowing of methylisothiazolinone (MI) in cosmetics, cleaning products, and paints, an epidemic of MI-hypersensitivity emerged. Importance Contact allergy to methylisothiazolinone (MI) or to the combined formulation of methylchloroisothiazolinone and MI (MCI-MI) has increased significantly, with a frequency of as much as 11.1% in patients with dermatitis; however, few cohort studies in the US population have been reported.. This entry was amended in order to add a new condition for MI/MCI when used in combination, as a prohibited substance in leave-on cosmetic products. It is a white solid that melts near room temperature. Date Created: May 12, 2012 Patch testing Kathon CG® (3:1 mixture of methylchloroisothiazolinone and methylisothiazolinone, MCI/MI) does not correctly detect MI contact allergy, due to the low concentration of MI in the test material. Methods.

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